You’ve noticed your skin looks a little tired. Maybe fine lines are lingering, your glow has faded, or your cheeks look flatter than they used to. You know there are treatments that can help, but the choice is overwhelming. Profhilo, fillers, polynucleotides, Sculptra, exosomes: what’s the difference, and which one do you actually need?

Demand for skin boosters in Birmingham has grown rapidly, and so has the menu. Each treatment works in a different way and solves a different problem. Pick the right one and the results can be remarkable. Pick the wrong one and you may pay for a change you didn’t want.

Our clinical team at Dermoperfection have created a guide to walk you through every hydrating and rejuvenating treatment we offer at our city centre Mailbox clinic.

We explain how each works, what it treats, and how they compare on results, downtime, treatment areas, longevity and price, so you have all the facts to make the most informed decision.

So, what does your skin actually need?

Every treatment in this guide falls into one of four families. The quickest way to narrow your options is to work out which problem you’re trying to solve.

If your main concern is…	Your skin needs…	Treatments to consider
Dullness, dryness, dehydration, crepey texture	Hydration	Profhilo, mesotherapy, EXION Face
Thin, fragile or sensitive skin, dark circles, slow recovery	Regeneration	Polynucleotides (Plinest, Rejuran), exosomes
Gradual loss of firmness and structure, early hollowing	Collagen stimulation	Sculptra, Juläine, HArmonyCa, Profhilo Structura
Hollow cheeks, deep folds, soft jawline, thin lips	Volume and shape	Dermal fillers, HArmonyCa

Most people see themselves in more than one row. That’s normal. Skin ageing is rarely one thing, and many of our best results come from combining treatments from different families. Think of it like a sofa: hydration and regeneration recondition the fabric, collagen stimulators strengthen the frame, and fillers replace the cushion stuffing.

Skin boosters: Profhilo in Birmingham

Profhilo: the injectable moisturiser

Profhilo is the best-known skin booster in the UK. Made by the Swiss pharmaceutical company IBSA, each 2ml syringe contains 64mg of pure hyaluronic acid, one of the highest concentrations available. Its high and low molecular weight forms are bound by a patented heat process rather than chemical cross-linkers, giving it a runny, spreadable texture.

It is injected at just five points on each side of the face (the Bio Aesthetic Points technique) and spreads evenly beneath the skin. As it slowly releases, it draws in water and stimulates collagen and elastin. The result is plumper, bouncier, more radiant skin, without any change to your features.

• Best for: dullness, dehydration, crepey skin, fine lines, mild laxity
• Areas: face, neck, décolletage, hands, arms, knees
• Course: 2 sessions, 4 weeks apart
• Results: hydration within 1 to 2 weeks; lasts around 6 months
• Price: £575 for a full course of 2

Profhilo Structura: support for the midface

Profhilo Structura is a newer, stronger member of the family. Rather than hydrating the skin surface, it targets the fat layer beneath the cheeks, restoring support for people whose midface has started to sag or look sunken.

It is injected by cannula in front of the ear and doesn’t add volume like a filler. Instead, it thickens and firms the tissue, softening the look of hollows and heaviness around the cheeks and eyes.

• Best for: early midface sagging, hollowing under the cheekbones
• Course: 2 sessions, 1 month apart, with a review after 4 months
• Price: £575 for a full course of 2

Profhilo and Profhilo Structura can be combined: Structura for support, classic Profhilo for surface skin quality.

Regenerative boosters: Polynucleotides

If Profhilo hydrates, polynucleotides repairs. They are highly purified fragments of DNA, derived from fish such as salmon or trout, that act as building blocks and signals for your skin’s own repair cells. They encourage fibroblasts to renew collagen and elastin, calm inflammation and support healthier tissue over time.

Polynucleotides are especially valued for delicate areas where other injectables are less suitable, most notably under the eyes, where fillers can cause puffiness or a bluish tint.

We offer two leading brands:

• Plinest, an Italian polynucleotide used for the face, eyes, neck and scalp
• Rejuran, a Korean formula popular for skin texture, pores and overall healing

At a glance:

• Best for: thin or crepey under-eyes, dark circles, fragile or sensitive skin, acne scarring, early fine lines
• Areas: under-eyes, full face, neck, lips and mouth area, scalp
• Course: usually 3 sessions, 2 to 4 weeks apart
• Results: build gradually over 4 to 8 weeks as skin quality improves
• Downtime: small bumps at injection points for 1 to 2 days
• Price: from £300 per 2ml session; full face 4ml course of 3 (including eyes) £1,400

Polynucleotides work well as a foundation treatment before or alongside Profhilo, particularly if your skin is thin and needs strengthening before it can benefit from hydration.

Collagen stimulators: Sculptra, Juläine and HArmonyCa

Collagen stimulators, also called biostimulators, are the long game of skin rejuvenation. Rather than adding hydration or volume directly, they trigger your body to build new collagen over several months. The results develop slowly, look entirely natural, and last longer than most other injectables.

Sculptra

Sculptra contains poly-L-lactic acid (PLLA), a biocompatible substance that activates collagen-producing cells as it is gradually absorbed. It is ideal for people with overall collagen loss: hollowed temples, sunken cheeks, softening of the jawline and a general thinning of the face.

• Course: usually 2 to 3 sessions, several weeks apart
• Results: develop over weeks to months; can last up to two years
• Price: £595 for 1 vial, £895 for 2 vials

Juläine

Juläine is a new-generation PLLA injectable that works in a similar way to Sculptra, stimulating fibroblasts to rebuild collagen and skin density. Our medical team trained with the brand on Harley Street.

• Best for: volume loss, mild to moderate laxity, thinning skin across the cheeks, temples, jawline and folds
• Course: 2 to 3 treatments, several weeks apart
• Results: develop over 8 to 12 weeks; designed to last up to two years
• Price: £850 per treatment, £2,195 for a package of 3

With both PLLA treatments, you’ll be asked to massage the area for a few days afterwards to help the product settle evenly.

HArmonyCa

HArmonyCa by Allergan is a hybrid. It combines hyaluronic acid filler for instant lift with calcium hydroxylapatite microspheres that keep stimulating collagen for months afterwards. You get the immediate result of a filler and the lasting benefit of a biostimulator in one treatment.

• Best for: midface volume loss, mild to moderate jowls, lines running from the ears towards the mouth
• Results: immediate lift, improving further over time; lasts up to 24 months
• Price: £695 per treatment, £995 for 2 syringes

Dermal fillers: volume and structure

Dermal fillers are also made from hyaluronic acid, but cross-linked into a firmer gel designed to stay exactly where it is placed. Rather than spreading like Profhilo, filler holds its shape, lifting and supporting tissue that has lost structure with age.

We use premium brands including Juvéderm and Teoxane, choosing a firmer gel for structure (cheeks, jawline, chin) and a softer one where movement matters (lips).

• Best for: hollow cheeks and temples, deep nasolabial folds and marionette lines, soft jawline, under-eye hollows, lip shape and volume
• Areas: cheeks, temples, lips, chin, jawline, tear troughs, folds
• Results: visible immediately; settled within about 2 weeks
• Longevity: lips 6 to 12 months; tear troughs around 12 months; cheeks and jawline 12 to 18 months
• Downtime: possible swelling or bruising for a few days
• Price: from £350 per 1ml syringe; lip filler from £200

Hyaluronic acid fillers can be dissolved if needed, an important safety advantage when they are placed by an experienced medical injector.

Gentler options: mesotherapy, exosomes and EXION Face

Not everyone is ready for injectables, and not every skin needs them. These treatments boost hydration and radiance with fewer or no injections, and they make excellent maintenance between bigger treatments.

Mesotherapy

Mesotherapy uses tiny, superficial micro-injections to deliver a tailored blend of hyaluronic acid, vitamins, antioxidants, peptides and amino acids into the skin. Unlike Profhilo, the cocktail can be customised, so it can target dullness and uneven tone as well as dehydration. We use professional protocols including Mesoestetic.

• Best for: dull, dehydrated skin, uneven tone, early fine lines, tired under-eyes
• Course: a series of sessions, tailored at consultation
• Price: £350 for full face; under-eye mesotherapy from £150 per session

Exosomes with microneedling

Purasomes exosome treatment pairs microneedling with a serum containing billions of exosomes, tiny cell messengers that carry repair signals and growth factors. Applied through the micro-channels, they support collagen renewal, calm inflammation and speed recovery.

• Best for: texture, radiance, mild scarring, reactive or redness-prone skin
• Course: usually 3 sessions, about 4 weeks apart
• Price: £375 to £425 per session; course of 3 from £995

EXION Face: needle-free hydration

EXION Face is an energy-based alternative for people who’d rather avoid needles altogether. It combines radio-frequency with targeted ultrasound to prompt your skin to make more of its own hyaluronic acid, collagen and elastin. It’s gentle enough for the eye area and has no downtime.

• Best for: needle-averse patients, fine lines, hydration, delicate areas
• Course: 4 to 6 sessions, 1 to 2 weeks apart
• Price: £249 per session; £995 for a course of 6 (4 + 2 free)

Every treatment at a glance

Here’s how all the hydrating and rejuvenating treatments at our Mailbox clinic compare. Longevity and downtime vary from person to person; these are typical guides.

Treatment	Main benefit	Best areas	Results appear	Downtime	Typically lasts	From
Profhilo	Hydration, bounce, glow	Face, neck, décolletage, hands	1 to 4 weeks	Small bumps, 24 to 48 hrs	Around 6 months	£575 (course of 2)
Profhilo Structura	Midface support	Cheeks, around eyes	2 to 4 weeks	Minimal	Review at 4 months	£575 (course of 2)
Polynucleotides	Repair and strengthening	Under-eyes, face, neck	4 to 8 weeks	Small bumps, 1 to 2 days	6 to 12 months	£300 per session
Sculptra	Collagen rebuilding	Temples, cheeks, jawline	Weeks to months	Swelling or bruising, few days	Up to 2 years	£595 per vial
Juläine	Collagen rebuilding	Cheeks, temples, jawline, folds	8 to 12 weeks	Swelling or bruising, 24 hrs	Up to 2 years	£850 per treatment
HArmonyCa	Instant lift + collagen	Midface, jowls	Immediate, then builds	Swelling or bruising, few days	Up to 24 months	£695 per treatment
Dermal fillers	Volume and shape	Cheeks, lips, jawline, chin, tear troughs	Immediate	Swelling or bruising, few days	6 to 18 months	£350 per 1ml
Mesotherapy	Hydration and radiance	Face, under-eyes	1 to 2 weeks	Redness, a few hours	Course-dependent	£150 per session
Exosomes + microneedling	Texture and recovery	Face	1 to 2 weeks	Pinkness, 24 to 48 hrs	Course-dependent	£375 per session
EXION Face	Needle-free hydration	Face, eyes, neck	1 to 2 weeks	None	Course-dependent	£249 per session

All prices are subject to consultation. See our full price list.

Combining treatments: example plans

The most natural results usually come from treating more than one layer of the face. These examples show how our clinicians often combine treatments. Your own plan will be tailored at consultation.

“My skin looks dull and dehydrated, but nothing else has changed.” Late twenties to thirties

• Start with a Profhilo course of 2
• Maintain with mesotherapy or EXION Face between top-ups

“I look tired, especially around my eyes.”

• Polynucleotides under the eyes (course of 3)
• Profhilo for the wider face
• Filler in the tear troughs only if hollowing remains once skin quality has improved

“My face has lost shape and my skin has lost bounce.” Forties and beyond

• Filler or HArmonyCa to restore structure in the cheeks and jawline
• Profhilo or Profhilo Structura around 2 weeks later
• A collagen stimulator such as Sculptra or Juläine for longer-term support

“I want gradual, long-lasting change without looking ‘done’.”

• A course of Sculptra or Juläine to rebuild collagen over several months
• Profhilo for surface hydration and glow

“I don’t want needles.”

• EXION Face for hydration and firmness
• Pair with ULTRAcel Q+ for deeper lifting if needed

Skin boosters and fillers in Birmingham at Dermoperfection

Dermoperfection is an award-winning, CQC-registered medical skin and aesthetics clinic at The Mailbox in Birmingham city centre, rated Good in all areas. With more than 15 years of industry experience and over 50,000 treatments performed, our team of doctors, nurses and advanced practitioners is trained in facial anatomy and advanced injectable techniques.

We were one of the first clinics to offer Profhilo when it launched, and every product we use is genuine, traceable and bought through official UK suppliers. Because we offer every treatment in this guide under one roof, our advice isn’t limited to whatever a clinic happens to stock. We recommend what your skin actually needs.

Book your medical skin consultation

Still not sure which treatment is right for you? That’s exactly what a consultation is for. At our city centre Mailbox clinic, your clinician will:

• Assess your skin quality, facial structure and areas of concern
• Talk through your goals, medical history and budget
• Recommend the right treatment, or combination, with a clear plan and pricing

There’s no pressure to book treatment on the day.

• Discover More About Profhilo
• Discovery More About Dermal Fillers
• Book Your Skin Consultation

Prefer to talk first? Call us on 0121 439 4350 or visit us at Level 2, Unit 56, The Mailbox, Birmingham B1 1RE.

Collagen is the scaffolding that keeps skin firm and smooth. From our mid-twenties we make roughly 1% less of it each year, and by our forties the change shows: softer jawlines, crepey necks, lines that stay put after a smile fades.

For a long time the only real answers were surgery, lasers with a week of recovery, or injectables that add volume without improving the skin itself. Energy-based devices have changed that. The most advanced of them work with your body rather than against it, prompting your own skin to rebuild. That’s why demand for EXION radio-frequency needling in Birmingham has grown so quickly.

In this guide, our clinical team at Dermoperfection explain what EXION is, how radio-frequency, microneedling and hyaluronic acid stimulation work together, and exactly what happens before, during and after a session.

What is EXION?

EXION is a multi-applicator skin and body platform made by BTL, the medical technology company behind EMSCULPT NEO and EMFACE. Rather than one device doing one job, it brings several treatments together, each with its own hand piece, and uses built-in artificial intelligence to monitor the skin and adjust energy as it works.

At our Mailbox clinic, the EXION platform covers:

• EXION Face. A needle-free applicator that pairs radio-frequency with targeted ultrasound to boost hydration, firmness and elasticity. It is gentle enough for delicate areas such as around the eyes.
• EXION Fractional RF (RF microneedling). Fine microneedles combined with radio-frequency energy for deeper remodeling of wrinkles, acne scars, stretch marks and texture.
• EXION Body. Radio-frequency and targeted ultrasound with active cooling, used to tighten loose skin and reduce stubborn fat on areas like the abdomen, arms and thighs.
• EXION Clear RF. A resurfacing option for sun damage, uneven pigment and texture.

This guide focuses on the two facial treatments people ask us about most: EXION Face and EXION RF microneedling. Used alone or together, they target wrinkles and skin laxity without the recovery time of surgery or ablative lasers.

The science made simple: Radio-frequency, microneedling and hyaluronic acid

EXION combines three proven ways of waking up your skin’s repair cells, called fibroblasts. Fibroblasts make collagen (for firmness), elastin (for bounce) and hyaluronic acid (for hydration and plumpness). With age and sun exposure they slow down. EXION’s job is to switch them back on.

1. Radio-frequency: controlled warmth that tightens

Radio-frequency (RF) is a form of energy that gently heats the deeper layer of skin, the dermis, without burning the surface. That warmth does two things. Existing collagen fibres contract, giving a subtle tightening you may notice soon after treatment. And the skin reads the heat as a signal to repair, so fibroblasts start producing fresh collagen and elastin over the following weeks and months.

Unlike lasers, RF energy doesn’t target pigment. That generally makes it a suitable option across a wide range of skin tones, which your clinician will confirm at consultation.

2. Microneedling: precision delivery below the surface

Microneedling creates thousands of tiny, controlled channels in the skin, triggering the natural wound-healing response. On its own, it is excellent for texture and scarring. Combined with RF, the needles act as delivery points, carrying heat straight into the dermis where collagen is made while leaving most of the surface untouched.

EXION adds two refinements. It’s AI monitors your skin and adjusts energy pulse by pulse, so each area gets the right dose. And its Extended Mode projects heat beyond the tip of the needle, reaching up to 8mm deep according to BTL. That means deep remodeling in a single pass, with less discomfort than older RF microneedling devices that needed multiple passes.

3. Hyaluronic acid stimulation: hydration from within

Hyaluronic acid (HA) is the molecule behind plump, dewy skin, and the main ingredient in many fillers and skin boosters. EXION Face takes a different route. It pairs RF with targeted ultrasound, which creates gentle mechanical stress in the skin. Together they prompt fibroblasts to make more of your own HA.

In BTL’s clinical studies, EXION Face was reported to increase natural hyaluronic acid by up to 224%, collagen by 47% and elastin by 50%. These are manufacturer-sponsored figures, and individual results vary, but they explain why patients describe a fresher, more hydrated look without needles or injections.

Why combining them works

Each technology does a different job. RF microneedling remodels deeper structure and texture. EXION Face restores hydration and elasticity across delicate areas. Many of our patients get the best results from a plan that uses both, timed so each treatment supports the next.

What can EXION treat?

EXION suits people who want firmer, smoother, healthier-looking skin rather than a changed face. At our Birmingham clinic we most often use it for:

• Fine lines and wrinkles, including around the eyes and mouth
• Mild to moderate skin laxity along the jawline, lower face and neck
• Crepey skin on the neck, décolletage and hands
• Acne scarring and uneven texture
• Enlarged pores and dull, dehydrated skin
• Stretch marks and loose skin on the body

Who is a good candidate?

EXION RF microneedling and EXION Face are a popular choice if you:

• Are noticing early to moderate signs of ageing and want to act before surgery is on the table
• Want non-surgical skin tightening with little or no time off work
• Have acne scars or textured skin that hasn’t responded to facials or peels
• Prefer to avoid injectables, or want to improve skin quality alongside them
• Have darker skin and want a resurfacing option with a lower pigment risk than many lasers

It may not be suitable if you are pregnant or breastfeeding, have a pacemaker or metal implants in the treatment area, have an active skin infection or open acne, or have recently used isotretinoin (Roaccutane). Your clinician will review your full medical history before recommending treatment.

Your EXION treatment: before, during and after

Knowing what to expect makes the whole experience easier. Here’s how a typical EXION RF microneedling or EXION Face appointment runs at our Mailbox clinic.

Before your session

Every EXION journey starts with a consultation. Your clinician assesses your skin, talks through your goals and medical history, and recommends the right applicator, settings and number of sessions.

In the week or two before treatment, we usually advise you to:

• Avoid sunbeds and strong sun exposure, and wear SPF 30 or higher daily
• Pause retinoids, exfoliating acids and scrubs for 3 to 5 days
• Let us know about any cold sores, as we may suggest antiviral medication beforehand
• Arrive with clean skin and no make-up if you can

During your session

EXION RF microneedling

1. Your skin is cleansed and a numbing cream is applied for around 30 to 45 minutes.
2. Your clinician moves the hand piece across each area in a single pass. The AI adjusts energy in real time as it goes.
3. Most people feel warmth and a light prickling or vibrating sensation rather than pain.
4. A soothing product and SPF are applied before you leave.

The treatment itself takes around 30 to 45 minutes, plus numbing time.

EXION Face

1. Your skin is cleansed and a conductive gel is applied. No numbing is needed.
2. Your clinician glides the applicator over the treatment areas, delivering RF and targeted ultrasound together.
3. You’ll feel gentle warmth. Many patients find it relaxing.

A full face session takes around 45 minutes, and eye rejuvenation around 15 minutes.

After your session

EXION Face has no downtime. Your skin may look slightly flushed for an hour or so, and you can return to work straight away.

EXION RF microneedling has minimal downtime. Expect:

• Redness, similar to mild sunburn, for 24 to 48 hours
• Mild swelling and a feeling of tightness for a day or two
• Tiny grid marks on the skin in some cases, fading within a few days

For the best recovery and results:

• Keep skin clean and use only the gentle products we recommend for 48 hours
• Skip make-up for 24 hours
• Avoid saunas, hot yoga, intense exercise and swimming for 48 hours
• Wear a broad-spectrum SPF every day, and avoid direct sun for two weeks
• Leave retinoids and active acids out of your routine for around 5 to 7 days

Results, courses and prices

EXION works with your skin’s natural renewal cycle, so results build gradually rather than appearing overnight.

• EXION Face: many patients notice a fresher, more hydrated look within a week or two. Firmness and elasticity keep improving across the course.
• EXION RF microneedling: skin often looks smoother within a few weeks. New collagen continues to form for 3 to 6 months after your final session, so the best results arrive well after treatment ends.

How many sessions will I need?

One session gives a visible boost, but a course delivers the most noticeable and longer-lasting change. As a guide:

• EXION RF microneedling: a course of 3 sessions, spaced 4 to 6 weeks apart
• EXION Face: a course of 4 to 6 sessions, spaced 1 to 2 weeks apart
• Maintenance: one top-up session every 6 to 12 months

Your clinician will tailor this to your skin, age and goals.

EXION prices at Dermoperfection

Course packages give the best value, with EXION Face courses including 2 free sessions.

Treatment	Single session	Course
EXION RF microneedling (face)	£550	£1,350 for 3 sessions
EXION Face	£249	£995 for 6 (4 + 2 free)
EXION Full Face, Neck & Eyes	£475	£1,600 for 6 (4 + 2 free)
EXION Eye Rejuvenation	£165	£660 for 6 (4 + 2 free)
EXION Neck & Chest	£249	£995 for 6 (4 + 2 free)
EXION Body (1 area)	£249	£995 for 6 (4 + 2 free)

All prices are subject to consultation. See our full price list.

EXION vs other skin tightening treatments at Dermoperfection:

EXION is one of several premium technologies we use for skin tightening at our city centre clinic. Each works at a different depth and suits a different concern, and many patients combine them.

Treatment	How it works	Typical downtime	Best for	From
EXION RF microneedling	AI-guided RF delivered through microneedles	24 to 48 hours of redness	Wrinkles, laxity, acne scars, texture	£550
EXION Face	RF + targeted ultrasound, no needles	None	Hydration, fine lines, delicate areas	£249
ULTRAcel Q+	Focused ultrasound (HIFU) to the deep support layer	Minimal	Lifting the jawline, jowls and brow	£550
INTRAcel Pro	Fractional RF microneedling	1 to 3 days	Scarring, pores, texture	£595
Fractional CO2 laser	Ablative laser resurfacing	5 to 7 days	Deep lines and significant scarring	£400

A popular pairing is ULTRAcel Q+ for deep lifting with EXION for the skin’s surface quality. HIFU tightens the foundations; EXION rebuilds collagen, elastin and hydration in the layers you see. Your clinician will suggest the combination that fits your skin and budget.

Why Choose Dermoperfection:

Where you are treated really matters, RF microneedling uses real energy at real depth. In the untrained hands, it can cause burns, pigment changes or scarring. When choosing a clinic, look for:

• Registration with the Care Quality Commission (CQC)
• Treatment delivered by medically trained clinicians
• Genuine, manufacturer-supplied devices and consumables
• A proper consultation covering your medical history, risks and realistic results

Dermoperfection is a CQC-registered clinic, rated Good in all areas, and all our devices and products are sourced directly from approved manufacturers and suppliers.

EXION radio-frequency needling in Birmingham at Dermoperfection

Dermoperfection is an award-winning medical skin and aesthetics clinic at The Mailbox in Birmingham city centre. With more than 15 years of industry experience and over 50,000 treatments performed, our team of doctors, nurses and advanced practitioners bring together the UK’s leading energy-based devices under one roof, including EXION, ULTRAcel Q+, INTRAcel Pro and EMFACE.

Ready to start? Book a consultation. You’ll get a full skin assessment, a tailored plan and clear pricing, with no pressure to book on the day.

Book your EXION treatment or consultation

Prefer to talk first? Call us on 0121 439 4350 or visit us at Level 2, Unit 56, The Mailbox, Birmingham B1 1RE.

For years, anti-ageing treatments worked from the outside in. Fillers replaced lost volume, and anti-wrinkle injections relaxed the muscles behind expression lines. Regenerative aesthetics takes a different approach: it gives your skin the signals it needs to repair and renew itself.

Exosomes are at the centre of that shift. They are one of the fastest-growing topics in aesthetic medicine, and demand for an exosomes skin treatment in Birmingham has risen sharply as patients look for results that look like their own skin, only healthier.

In this guide, our clinical team at Dermoperfection explain what exosomes are, how Purasomes face treatment works, why exosomes pair so well with microneedling, and what the evidence does and doesn’t yet show. By the end, you’ll know whether exosome therapy belongs in your skin plan.

What are exosomes?

Exosomes are tiny messengers that cells release to talk to each other. They are extracellular vesicles, roughly 30 to 150 nanometres across, which is around a thousand times smaller than the width of a human hair.

Each exosome is a small bubble with a protective lipid membrane. Inside, it carries proteins, lipids, growth factors and genetic material such as microRNA. When an exosome reaches another cell, it delivers that cargo and can influence how the cell behaves.

In skin, this communication matters. Laboratory and animal research suggests exosomes can:

• Encourage fibroblasts, the cells that make collagen and elastin, to become more active
• Help calm inflammation after skin is stressed or injured
• Support the repair of the skin barrier and hydration
• Promote new blood vessel growth, which feeds healing tissue

This is why exosomes are described as “cell-free” regenerative therapy. They deliver many of the signaling benefits linked to stem cells, without introducing any living cells into your skin.

If you’d like a broader primer on how skin repairs itself, read our guide to the science of self-repair in regenerative aesthetics.

Purasomes face treatment: Exosomes designed for aesthetic practice

Not all exosome products are the same. They can come from human cells, plants or animals, and quality varies widely. At Dermoperfection we use Purasomes, a professional-only range made by the Italian research company Dermoaroma and distributed in the UK by DermaFocus.

Each Purasomes vial contains around 20 billion exosomes and 20 growth factors, using Dermoaroma’s patented AMPLEX Plus technology. The exosomes are purified from ethically sourced bovine colostrum, the nutrient-rich first milk a cow produces after calving, which is naturally rich in growth factors, peptides and extracellular vesicles.

There are two formulas for the face:

• Purasomes Skin Glow Complex (SGC100+) focuses on radiance, uneven tone and dullness
• Purasomes Skin Nutri Complex (NC150+) targets tired, dehydrated and ageing skin that needs deeper renewal

A third formula, the Hair & Scalp Complex (HSC50+), is designed for thinning hair. Dermoperfection offers the full Purasomes range, your clinician will choose the formula that matches your skin goals at consultation.

Purasomes are applied to the skin during microneedling rather than injected. That delivery method is the key to how they work.

How exosomes supercharge microneedling:

Microneedling has long been one of the most trusted treatments for texture, fine lines, enlarged pores and acne scarring. It creates thousands of controlled micro-channels in the skin, which triggers your natural wound-healing response and prompts new collagen.

Those same micro-channels also give active ingredients a direct route past the skin’s surface. Adding exosomes at this moment means the repair signals arrive exactly when and where your skin is primed to respond.

What exosomes add to microneedling

• Faster recovery. Exosomes help calm post-treatment inflammation, so redness typically settles sooner than with microneedling alone.
• Better texture results. Extra signaling to fibroblasts supports collagen and elastin renewal, helping skin look smoother and more refined.
• Improved tone and radiance. Many patients notice a brighter, more even complexion as the skin barrier recovers.
• Comfort for reactive skin. The calming effect makes the combination a good option for skin prone to redness.

What happens during treatment:

1. Your skin is cleansed and a numbing cream is applied for comfort.
2. Your clinician microneedles the treatment area at a depth tailored to your concerns.
3. The Purasomes formula is applied across the skin and worked into the micro-channels, often with a second pass.
4. Aftercare products and SPF guidance are given before you leave.

Most treatments take around 60 to 75 minutes including numbing. Expect some pinkness for 24 to 48 hours, and a course of three sessions spaced about four weeks apart is typical.

Exosomes vs other skin boosters

Exosomes are one part of a wider family of regenerative skin boosters. Each works in a different way, and many patients get the best results by combining them.

Treatment	How it works	Delivered by	Best for
Exosomes (Purasomes)	Carries cell-to-cell repair signals and growth factors	Applied during microneedling	Texture, radiance, recovery, reactive skin
Polynucleotides	DNA fragments that support tissue repair and fibroblast activity	Injection	Under-eyes, crepey skin, thin or fragile skin
Profhilo	High-concentration hyaluronic acid that hydrates and remodels	Injection	Hydration, laxity, overall skin quality
PRP	Growth factors concentrated from your own blood	Injection or microneedling	Patients who prefer an autologous option

The right choice depends on your skin, your goals and your timeline. That’s why every regenerative plan at Dermoperfection starts with a consultation rather than a menu.

Who is suitable for exosome therapy?

Exosome treatment suits people who want healthier-looking skin rather than a changed face. It is a popular choice if you:

• Have dull, tired or uneven skin that no longer responds to skincare alone
• Want to improve texture, pores or mild to moderate acne scarring
• Are noticing early signs of ageing such as fine lines and loss of bounce
• Have sensitive or redness-prone skin and want a gentler regenerative option
• Want faster, more comfortable recovery from microneedling

It may not be suitable if you are pregnant or breastfeeding, have an active skin infection or open acne in the area, or have a known allergy to bovine or dairy-derived ingredients. Your clinician will review your medical history before recommending treatment.

When will I see results?

Most patients see a fresher, more hydrated glow within one to two weeks. Collagen renewal takes a little longer, so texture and firmness continue to improve over the following two to three months. Results vary from person to person, and a maintenance session every six to twelve months helps sustain and expand the results

Why where you’re treated matters:

The exosome market has grown quickly, and not every product or provider meets medical standards. When choosing a clinic, look for:

• A clinic registered with the Care Quality Commission (CQC)
• Treatment delivered by medically trained clinicians
• Genuine, traceable products bought through official UK distributors
• A proper consultation that covers your medical history, risks and realistic results

Dermoperfection is a CQC-registered clinic, rated Good in all areas, and all our products are sourced directly through approved suppliers, so you know that you are in trusted and safe hands.

Regenerative aesthetics in Birmingham at Dermoperfection

Dermoperfection is a medical skin and aesthetics clinic at The Mailbox in Birmingham city centre. With more than 15 years of industry experience and over 50,000 treatments performed, our team of medically clinicians  have been working and training with the leading brands at the forefront of regenerative aesthetics in the UK.

We don’t offer exosomes as a stand-alone trend. We build them into personalised programmes alongside microneedling, polynucleotides, skin boosters and medical-grade skincare, so each treatment supports the next and our patients received the best possible results and care.

Book your Exosome Skin Regeneration Consultation

Your consultation includes a full skin assessment, a discussion of your goals and medical history, and a tailored plan with clear pricing. There’s no pressure to book treatment on the day. 

Book your Exosome Skin Regeneration Consultation

Prefer to talk first? Call us on 0121 439 4350 or visit us at Level 2, Unit 56, The Mailbox, Birmingham B1 1RE.

We celebrating our 4th Birthday, and we are inviting you to join us at the Mailbox in Birmingham for all the action!

This October 16th – 19th is officially the Dermoperfection 4th Birthday Weekender!

Over four full days, we are hosting our biggest celebration yet at Dermoperfection in The Mailbox, Birmingham to thank all our patients for their support over the years and celebrate four amazing years of radiant glowing skin.

We are pulling out all the stops to make this weekend unforgettable. Expect giveaways, goodies and much more! Be sure to follow all the action on our Social channels to be the first to know all the exclusive details.

Save the Date

• When: 16th – 19th October

• Where: Dermoperfection, The Mailbox, Birmingham

• TBA Headline Feature

Choosing where to have Botox is every bit as important as deciding to have it at all. The right clinic protects not only your results but your safety, while the wrong choice can lead to disappointment or, occasionally, complications. As a medically led clinic, we believe you deserve to feel completely confident in that decision, so our clinical team has put together this honest guide to choosing a Botox clinic in Birmingham. For an overview of our own approach, you can also read about Botox in Birmingham.

Your Botox clinic checklist

Before you book anywhere, it helps to know what genuinely matters. The checklist below summarises the essentials a reputable clinic should offer, every one of which we consider non negotiable.

What to check	Why it matters
The injector is a medical professional	Doctors, dentists, nurses and qualified prescribers are trained to handle complications
A face to face consultation is offered	Botox should never be administered without an individual assessment
The clinic is clean and clinical	Sterile, professional surroundings reduce the risk of infection
Genuine, traceable product is used	Confirms you are receiving a regulated, prescription medicine
Aftercare and a follow up are included	Shows the clinic stands behind its results and your safety
Honest, verifiable reviews and before and after photos	Evidence of real, consistent results from real clients

Is your injector medically qualified?

This is the single most important question of all. Botox is a prescription only medicine, and it should only ever be prescribed and administered by a qualified medical professional such as a doctor, dentist or nurse prescriber. A medically trained injector understands facial anatomy in depth and, crucially, knows how to manage the rare occasions when something does not go to plan. At our clinic, every treatment is carried out by our highly experienced clinical team, so you are always in safe, expert hands.

How Botox pricing works, and why very cheap is a warning sign

It is natural to consider cost, but Botox is one area where the lowest price is rarely the wisest choice. Genuine botulinum toxin, a properly qualified prescriber and a clean clinical setting all carry a real cost, so a price that seems too good to be true often is. Suspiciously cheap offers can point to diluted product, unqualified injectors or unsafe surroundings. We believe in honest, transparent pricing that reflects genuine quality and safety. You can review our own price list or read more about how much Botox costs to understand fair value.

Questions worth asking

A trustworthy clinic will welcome your questions rather than rush past them. It is entirely reasonable to ask what medical qualification your injector holds, which product will be used, how many units you will receive and what happens if you are not satisfied with your result. You might also ask about follow up appointments and how complications would be managed. The confidence and clarity of the answers will tell you a great deal about the clinic’s standards.

How to check reviews and credentials

Independent reviews, genuine client photographs and verifiable credentials are among the most reliable signals of a good clinic. Look for consistent, natural looking results rather than dramatic before and after images, and check that the practitioner is registered with the appropriate professional body. You are always welcome to view our own before and after photos, which reflect the natural, refined results our clients come to us for.

Red flags to walk away from

Some warning signs are worth taking seriously. Be wary of treatments offered without any consultation, prices that seem far below the market, vague answers about who is actually performing your treatment, pressure to commit on the spot, or settings that feel more like a living room than a clinic. Any one of these is reason enough to pause. Your face and your wellbeing are simply too important to gamble on. Trust your instincts too. If something about a clinic feels rushed, evasive or unprofessional, it is perfectly acceptable to thank them for their time and look elsewhere. A reputable clinic will always respect your right to take treatment at your own pace.

What a good consultation looks like

A proper consultation is the foundation of safe, beautiful results. During your consultation with us, one of our clinicians will discuss your concerns, assess your facial muscles, talk through your medical history and design a treatment plan tailored entirely to you. There is never any pressure. We would far rather you felt fully informed and at ease than rushed into a decision.

Why aftercare and follow up matter

Good treatment does not end when you leave the room. A reputable clinic provides clear aftercare guidance and offers a follow up to review your results and make any small adjustments. This is your reassurance that the clinic genuinely stands behind its work. Our guide to what not to do after Botox shows the kind of detailed aftercare you should expect, and you can read more about safety in our explanation of whether Botox is safe.

Why a local Birmingham clinic makes a difference

Choosing a clinic close to home brings real, practical benefits. It makes attending your consultation, treatment and follow up far easier, and it allows you to build an ongoing relationship with a team that comes to know your face and your preferences over time. That continuity of care is something we value enormously, and it is one of the quiet advantages of treating with a dedicated local clinic. Should you ever have a question between appointments, a nearby clinic is far easier to reach, and being able to pop in for a quick review gives real peace of mind.

Botox at Dermoperfection in Birmingham

Here at Dermoperfection in The Mailbox, Birmingham, every treatment is delivered by our medically qualified, highly experienced clinical team, in a calm and genuinely clinical setting. We are proud of our honest advice, our transparent pricing and the natural results our clients trust us for. If you are looking for a Botox clinic in Birmingham where you can feel completely at ease, we would be delighted to welcome you for a consultation.

Once you have chosen your clinic, our guides to Botox vs dermal fillers, Baby Botox and the Botox treatment areas we treat will help you plan your treatment.

Frequently asked questions

Is cheap Botox safe?

Not necessarily. A very low price can indicate diluted product, an unqualified injector or unsafe surroundings. Safe Botox relies on genuine medicine and a properly trained medical prescriber, which carry a real cost.

Do I need a consultation first?

Yes, always. Botox should never be given without a face to face assessment. A consultation lets the clinician review your suitability, plan your treatment and answer your questions.

Can a beautician do Botox?

Botox is a prescription only medicine and should be prescribed and administered by a qualified medical professional. We would always advise choosing a doctor, dentist or nurse prescriber.

How do I check a practitioner is registered?

You can ask directly about their medical qualification and check their registration with the relevant professional body. A reputable clinic will share this information happily.

What if I am not happy with the result?

A good clinic offers a follow up to review your results and make small adjustments where appropriate. We always invite you back so we can make sure you are delighted.

How far in advance should I book?

It is wise to book your consultation a couple of weeks ahead, especially before an event, so there is plenty of time for your results to settle fully beforehand.

One of the most common questions we hear at Dermoperfection is: “How long will lip fillers last?” In this article, we break down the science, influencing factors, and tips to maximise your investment in lip enhancements, specifically for clients in Birmingham and the West Midlands.

What Are Lip Fillers?

Lip fillers (typically hyaluronic acid-based dermal fillers) are injectable gels that add volume, contour, hydration, and definition to the lips. At Dermoperfection, we use only medically approved products administered by skilled clinicians in a safe clinical environment.

Our lip filler treatment in Birmingham uses premium Juvéderm lip fillers, a trusted brand renowned for its smooth, natural-looking results and long-lasting hydration.

Lip Filler Longevity by Product

Different lip filler products are formulated for different purposes, and their longevity varies meaningfully. The table below covers the lip-specific products from the major hyaluronic acid filler ranges used in UK clinics, including those we use at Dermoperfection.

Product	Manufacturer	Typical Longevity	Best For
Juvéderm Volbella	Allergan / AbbVie	9 to 12 months	Subtle enhancement, hydration, fine perioral lines. The most popular “starter” lip filler.
Juvéderm Volift	Allergan / AbbVie	12 to 15 months	Mid-range volume with shape and definition. A common step up from Volbella.
Juvéderm Ultra Smile	Allergan / AbbVie	9 to 12 months	Lip-specific formulation with added lidocaine for comfort. Soft, natural enhancement.
Restylane Kysse	Galderma	Up to 12 months	Lip-specific filler with flexible “XpresHAn” cross-linking that moves naturally with expression.
Teosyal RHA Kiss	Teoxane	9 to 12 months	Resilient hyaluronic acid designed for dynamic areas. Moves naturally with the lips.
Restylane Lyft / Defyne	Galderma	9 to 12 months	Firmer products occasionally used for structural lip work. Less common for first-time patients.

These figures are typical averages. Your individual results depend on the dose used, your metabolism, lifestyle factors, and the skill of your injector. At our Birmingham clinic, our clinicians will recommend the specific product best suited to your goals during your consultation.

Duration: Typical Timeframe

Most lip fillers last between 6 to 12 months. Some clients may see slight fading earlier (around 4-6 months), while others may maintain subtle results beyond 12 months, depending on many variables.

Key Factors That Influence Longevity

Factor	Influence on Filler Duration
Product type & concentration	Denser, cross-linked HA formulations tend to last longer
Your metabolism & lifestyle	High metabolic rate or habits like smoking may speed breakdown
Injection technique & location	Precise placement improves longevity; overfilled areas may migrate or dissolve faster
Aftercare, sun & skincare	Good aftercare, sun protection, and skincare preserve results
Frequency of top-ups	Maintenance sessions help sustain effect over time

Tips to Extend Lip Filler Results

• Hydrate well and maintain skin health
• Use SPF lip balm daily
• Avoid excessive sun, lip exfoliation or harsh treatments
• Stop smoking (if applicable)
• Attend recommended top-up appointments
• Choose a skilled clinician (like at Dermoperfection) who injects conservatively and with balance

What Happens When Fillers Fade

You may notice subtle softening, loss of crisp border, or mild volume reduction. Often the transition is gradual. 

If you’re considering lip fillers in Birmingham or the West Midlands, or want to book a review or top-up, contact Dermoperfection clinic. Let us help you achieve beautifully long-lasting, natural lip enhancements. Book here!

Frequently Asked Questions

How long until lip filler settles?
Lip filler typically takes 2 to 4 weeks to fully settle. The first 24 to 48 hours often involve noticeable swelling, which can make the lips look larger than the final result. Most of the swelling subsides within 5 to 7 days, and the filler integrates with the surrounding tissue over the following 2 to 3 weeks. Your final result is usually visible at the 4-week mark, which is when most clinicians schedule a review appointment.

How long does 0.5ml lip filler last?
A 0.5ml lip filler treatment typically lasts 6 to 9 months. This is the most popular starter dose for first-time patients and creates subtle, natural enhancement. Because the volume is smaller, the body breaks it down slightly faster than a full 1ml treatment. Many patients have a 0.5ml top-up at the 6 to 9 month mark, or build to 1ml gradually over several sessions.

Why do my lip fillers dissolve so fast?
There are several reasons lip filler may seem to dissolve faster than expected. The lips are one of the most mobile areas of the face, so constant movement from talking, eating, and expression breaks the filler down more quickly than in static areas like the cheeks. A faster metabolism, frequent strenuous exercise, smoking, sun exposure, and certain medications can all shorten longevity. Smaller doses (0.5ml) also break down faster proportionally than larger doses. If your filler is consistently dissolving within 3 to 4 months, talk to your clinician about whether a longer-lasting product (such as Juvéderm Volift) might be more suitable.

Does lip filler longevity change with age?
Yes, to a degree. Younger patients (typically under 30) often metabolise hyaluronic acid filler faster, meaning the same product may last 6 to 9 months for a 25-year-old but 9 to 12 months for a 45-year-old. This is because metabolic rate generally slows with age. Older patients also typically have less mobile lip movement and slightly drier tissue, both of which contribute to longer-lasting results. That said, individual variation is large — your personal metabolism, lifestyle, and product choice matter more than age alone.

Which brand of lip filler lasts longest: Juvéderm, Restylane, or Teosyal?
Of the three major brands, Juvéderm Volift typically offers the longest lip filler longevity at 12 to 15 months, due to its higher cross-linking and structural cohesion. Restylane Kysse and Teosyal RHA Kiss both typically last up to 12 months, with Restylane’s “XpresHAn” technology and Teosyal’s “Resilient Hyaluronic Acid” both designed to flex naturally with lip movement rather than maximise longevity. Juvéderm Volbella, the most popular starter product, lasts 9 to 12 months. The right product for you depends on your goals and lip anatomy, not just longevity.

If you are thinking about Dermal fillers, it is completely natural to have questions about safety. For many people, this is one of the most important parts of the decision-making process. You want to feel confident not just in the results, but in the treatment itself and the person carrying it out.

The good news is that dermal fillers are widely used and can be very safe when performed by a qualified and experienced practitioner. Understanding how these cosmetic treatments work and what to look for in a clinic can help you feel more reassured and in control of your decision. Whether you are considering a subtle cosmetic procedure or exploring different treatment areas, safety should always come first.

If you are new to treatment, you can explore more about the process on our dermal fillers in Birmingham page.

What Are Dermal Fillers?

Dermal fillers are injectable treatments used to restore facial volume, enhance facial features, and improve overall balance. They are commonly used in areas such as the lips, cheeks, and jawline, as well as for concerns like nasolabial folds, marionette lines, perioral lines, and other wrinkles linked to volume loss and skin ageing.

Most modern fillers are made from hyaluronic acid, a substance naturally found in the body that helps keep the skin hydrated and supported. Hyaluronic acid dermal fillers are widely used because this filler material integrates well into the facial tissues and supports natural-looking results.

Treatments are always tailored to your individual features. Some people want a soft refresh, while others are looking for more definition or structure. This may include lip augmentation, cheek augmentation, or treating frown lines, depending on your goals.

Are Dermal Fillers Safe?

Dermal fillers are considered safe when they are carried out by a trained and qualified practitioner using approved products in a clinical environment.

Safety is not just about the treatment itself, but how it is performed. A skilled injector with a strong understanding of facial anatomy will know exactly where and how to place filler safely. This includes selecting the correct injection sites and performing precise dermal filler injections and injections, which helps reduce risks and achieve balanced results.

Using high-quality, regulated products is essential. Reputable clinics will only use trusted injectables such as hyaluronic acid-based dermal fillers, ensuring both safety and consistency. Although fillers are a non-invasive technique, they are still a medical cosmetic procedure, so proper standards must always be followed.

A thorough consultation should always come first. This allows your practitioner to assess your suitability, review your chosen treatment areas, and create a personalised plan that aligns with your goals.

Possible Side Effects of Dermal Fillers

Like any aesthetic treatment, dermal fillers can have side effects. Most are mild and temporary, and are part of the normal healing process.

Common side effects include slight swelling, redness, tenderness, or mild bruising around the injection sites following dermal filler injections. These typically settle within a few days and are nothing to worry about.

More serious complications are less common, but they can happen. This is why choosing experienced aesthetic practitioners is so important. A knowledgeable practitioner can minimise risk, identify early signs of concern, and manage any adverse effects safely if needed.

Fillers are often used to soften wrinkles, restore facial volume, and treat areas such as nasolabial folds, marionette lines, and perioral lines, so careful planning and technique are always essential.

Professional Guidance Matters

Professional Guidance Matters
At Dermoperfection, every treatment plan begins with detailed facial analysis to ensure balanced, natural-looking results.

Book consultation

How to Choose a Safe Aesthetic Clinic

Choosing the right clinic is one of the most important parts of your treatment journey. It is not just about results, it is about feeling safe, supported, and confident throughout the process.

Look for a practitioner with medical training and a strong understanding of facial anatomy. A skilled injector will understand how to work with the skin, facial tissues, and correct injection sites to deliver safe and effective results.

A good consultation should feel calm and unhurried. Whether you are considering lip augmentation, cheek augmentation, or other injectables, you should feel comfortable asking questions and understanding your options.

It is also helpful to choose a clinic that focuses on natural results. A thoughtful approach to aesthetics often reflects a more careful and considered treatment style, particularly when treating areas affected by skin ageing.

Aftercare is another important factor. Clear aftercare instructions and guidance on post-treatment care should always be provided so you know how to support your healing after injections.

Dermal Fillers at Dermoperfection

At Dermoperfection, your safety and comfort are always the priority. Every treatment begins with a detailed consultation where you can take your time, ask questions, and fully understand what to expect.

The approach is always personalised and focused on natural results that feel right for you. Whether you are considering lip augmentation, restoring facial volume, or enhancing your overall features, your treatment plan will be tailored to suit you.

Dermal fillers can also support the appearance of the skin over time. Many patients are interested in how treatments relate to collagen, collagen production, and maintaining healthy skin as it naturally changes.

There is no pressure to go ahead. It is about helping you feel informed, supported, and confident in your decision.

If you are considering dermal fillers and would like to explore your options in a calm and welcoming environment, you are warmly invited to book a consultation here.