At Dermoperfection, an award-winning clinic in the Mailbox, we believe that the most effective aesthetic treatments work with your body — not against it. That’s why we specialise in regenerative skincare: a new era of aesthetics that focuses on stimulating your body’s natural repair and rejuvenation processes.

From cutting-edge innovations like Purasomes Exosomes and Plinest Polynucleotides to results-driven technologies like EMFACE and Fractional CO2 Laser, we offer a carefully selected portfolio of treatments that are both clinically backed and naturally powerful.

What Is Regenerative Skincare?

Regenerative skincare is based on the principle of activating the body’s own ability to heal, restore, and regenerate — without invasive procedures or aggressive treatments. Whether the goal is collagen production, cellular repair, or tissue renewal, these treatments encourage a biological response that enhances skin health from within.

The result? Natural-looking, long-term improvements in skin tone, texture, elasticity, and radiance.

Our Most In-Demand Regenerative Treatments:

Purasomes Exosomes
A revolutionary cell signalling treatment that promotes skin regeneration and repair by delivering high concentrations of growth factors and peptides. Ideal for improving texture, elasticity, and signs of ageing.

Plinest Polynucleotides
Derived from purified DNA fragments, polynucleotides support tissue regeneration at a cellular level. This injectable treatment restores skin density, hydration, and elasticity — perfect for age-related skin concerns.

EMFACE
A non-invasive facial treatment that simultaneously lifts, tones, and tightens using synchronised radiofrequency and HIFES™ technology. Think of it as a needle-free facelift, with zero downtime.

Fractional CO2 Laser
This gold-standard resurfacing treatment works by stimulating collagen through controlled micro-injuries in the skin. It’s ideal for tackling fine lines, pigmentation, scarring, and skin laxity.

Natural Results, Backed by Science

Each of our regenerative treatments is medically approved, clinically proven, and carefully tailored to your skin’s individual needs. Whether you’re seeking preventative care, rejuvenation, or restorative treatment, Dermoperfection offers a safe and advanced approach to achieving your goals.

Our award-winning clinic is trusted by patients across Birmingham and beyond for delivering natural-looking results — without compromise. Book your consultation today and discover how regenerative skincare can unlock your skin’s full potential.

Skin Cancer Awareness Month is a crucial reminder of the risks associated with prolonged sun exposure—and the importance of protecting your skin year-round. While the focus is rightly on prevention and early detection, it’s also important to address the long-term impact of UV radiation, including sun damage that may already be visible on the skin.

At award-winning Dermoperfection, based on Level 2 of The Mailbox in Birmingham, we regularly treat patients concerned about the lasting effects of sun exposure. From pigmentation and dehydration to fine lines and skin laxity, sun damage often becomes more pronounced over time—especially after years of tanning or skipping SPF.

The good news? Modern aesthetic medicine offers clinically proven, non-surgical solutions to treat and reverse these visible signs while promoting long-term skin health.

What Does Sun Damage Look Like?

Even though a tan may seem like a short-term glow, the long-term effects of UV exposure can lead to significant damage at a cellular level. Common signs include:

• Hyperpigmentation or uneven skin tone

• Dry, crepey or thinning skin

• Premature lines and wrinkles

• Reduced elasticity and sagging

• Dullness or loss of radiance

It’s also important to note that UV exposure is the primary cause of photoaging, responsible for up to 80% of visible ageing. Over time, these changes can increase the risk of skin cancers—another reason why prevention and repair go hand-in-hand.

Treatments We Recommend to Reverse Sun Damage

1. Profhilo: Deep Hydration for Damaged Skin

Profhilo is an injectable treatment rich in hyaluronic acid, designed to hydrate from within and rejuvenate tired, UV-damaged skin.

• Ideal for crepey, sun-damaged skin

• Boosts collagen and elastin

• Improves tone, firmness and glow

It’s especially beneficial for skin that feels tight, dull, or prematurely aged due to chronic sun exposure.

2. Plinest Polynucleotides: Cellular Regeneration

Plinest is part of a new class of regenerative injectables that harness filtered DNA fragments to support skin healing at a cellular level.

• Reduces pigmentation and textural changes

• Repairs oxidative damage caused by UV rays

• Stimulates natural tissue repair

This is a powerful, medical-grade option for those seeking visible skin renewal after years of sun damage.

3. HydraFacial: Antioxidant-Rich Skin Detox

HydraFacial combines deep cleansing, exfoliation and antioxidant infusion in one non-invasive treatment.

• Brightens sun-damaged, dull skin

• Fades surface pigmentation

• Restores hydration and defences

It’s also an excellent maintenance treatment after holidays or summer months, helping you reset your skin health.

SPF: The Essential Daily Defence

While treatments can repair damage, prevention remains the most powerful tool in your skincare arsenal. A broad-spectrum, medical-grade SPF is vital for protecting against UVA (ageing) and UVB (burning) rays—and essential to maintain your treatment results.

Our top SPF picks include:

• Obagi Sun Shield Matte,  Tinted or Cool SPF50

• Mesoestetic Melan 130+ Pigment Control

• PCA Skin Weightless Protection SPF45

We stock these and more in-clinic and online, so your skin is protected every day.

Start Your Skin Recovery Journey

Whether you’re looking to correct signs of sun damage or take proactive steps in your skincare, Dermoperfection’s expert medical team is here to help. Visit our award-winning clinic at The Mailbox to create your bespoke skin plan or shop our recommended sun protection products online.

Protect. Repair. Rejuvenate.
This Skin Cancer Awareness Month, take action for healthier, more resilient skin—for today and the future.

At Dermoperfection, we offer 88 expert treatments, delivering state-of-the-art, industry-leading, science-backed care with award-winning results, 7 days a week!

🏆PCA Skin’s Clinic of the Year 2024
🏆GHP Global Excellence Award: Best Aesthetic Clinic in Birmingham
🏆WhatClinic Patient Service Award 2024

Our expert team provides tailored treatment plans to achieve your skin and body goals.

Ready for the best? Book your consultation at our award-winning clinic in the Mailbox today!

WATCH THE REEL HERE FOR MORE!

We all want radiant, youthful-looking skin—but with busy schedules, most of us are looking for treatments that deliver immediate results, while also supporting longer-term skin health. At Dermoperfection, we offer advanced treatments designed to soften fine lines and wrinkles quickly, with continued results that improve over time.

Here are five of our favourite anti-ageing treatments that show visible results straight away—and keep getting better with time.

1. Anti-Wrinkle Injections (Botox)

If you’re looking for a go-to treatment to smooth dynamic wrinkles, Botox (anti-wrinkle injections) is the classic choice, and for good reason. It works by temporarily relaxing the facial muscles responsible for fine lines and creases, particularly on the forehead, around the eyes (crow’s feet), and frown lines.

• Results in: 3–7 days 
• Longevity: Up to 3–4 months 
• Why we love it: Instant softening effect and a refreshed, lifted appearance without surgery.

2. EMFACE Eyes

For those targeting the delicate eye area, EMFACE Eyes is a revolutionary non-invasive treatment that combines radiofrequency and HIFES technology to lift, tone and smooth, without needles.

It stimulates collagen production and muscle tone around the eyes, giving a natural, wide-awake, lifted look.

• Results in: Immediately visible tightening after first session 
• Longevity: Results build and peak over 6–12 weeks 
• Why we love it: Needle-free eye rejuvenation with visible firming and smoothing effects from the first session.

3. Polynucleotides (Plinest)

Known famously as the “fish sperm facial”, Polynucleotides are a powerful skin regenerative treatment derived from salmon trout DNA. These injectables are ideal for delicate areas like under the eyes, neck and décolletage, where skin often loses its elasticity first.

• Results in: Skin hydration immediately after treatment 
• Longevity: Cellular regeneration continues for weeks post-treatment 
• Why we love it: It boosts skin quality at a deep level and delivers long-term rejuvenation, not just a quick fix.

4. Profhilo

A game-changer in injectable skincare, Profhilo is not your typical filler, it’s a skin booster that fills your skin with high concentrations of hyaluronic acid, stimulating collagen and elastin production for firmer, more hydrated skin.

• Results in: Glowing, plumper skin in just a few days 
• Longevity: Peak results after 2 sessions, lasting up to 6 months 
• Why we love it: Immediate glow, long-term firmness, especially great for crepey skin and dullness.

5. HydraFacial

The HydraFacial is a favourite for a reason, it’s the ultimate skin refresh with no downtime. This multi-step facial deeply cleanses, exfoliates, and hydrates while infusing the skin with antioxidants and peptides.

• Results in: Instantly brighter, smoother, more hydrated skin 
• Longevity: Ongoing improvements with regular sessions 
• Why we love it: Instant red-carpet glow and the perfect prep before any big event or special occasion.

At Dermoperfection, we’re all about evidence-based treatments with real results. Whether you’re after a quick boost before a big event or want to invest in long-term skin health, our medical experts are here to help you find the perfect plan. Book consultation today and get started on your journey to visibly smoother, younger-looking skin

In-depth education, live demonstrations, 150+ giveaways, exclusive product launches, expert skin advice and more at our event last week in collaboration with DermaFocus and Plinest.

Thank you to everyone who joined us and got involved – we loved welcoming you!

We look forward to seeing you at our next event!

WATCH HERE!

We recently hosted an exclusive VIP evening with DermaFocus to celebrate the latest in regenerative aesthetics.

We spoke to some of our amazing guests on the night – here’s what they had to say!

WATCH HERE!

From pigmentation to acne scarring, the answers were honest and relatable — do you find you have similar concerns, or something else entirely?

Book a consultation with our medical experts at The Mailbox. We’ll analyse your skin and create a personalised treatment plan tailored to your needs.

WATCH HERE!

In the ever-evolving world of aesthetics, the future of skincare is already here—and it’s happening at the cellular level. If you’ve been hearing the buzz around Plinest Polynucleotides and Purasomes Exosomes, you’re not alone. These two treatments are leading a new wave in regenerative skin health, offering natural rejuvenation by working with your body, not against it.

But what exactly are cellular-level treatments — and why are they all the rage?

What Are Cellular-Level Treatments?

Cellular-level treatments target the skin’s innermost structures to stimulate repair, regeneration, and renewal from the inside out. Unlike surface-level procedures that focus on exfoliation or temporary plumping, these advanced treatments work deep within the skin to improve the function and vitality of skin cells themselves.

The stars of Regeneration are Plinest Polynucleotides and Purasomes Exosomes

Plinest is a regenerative injectable made from purified polynucleotides (derived from salmon trout DNA), known for their powerful ability to stimulate fibroblasts—cells responsible for producing collagen, elastin, and hyaluronic acid.

Benefits of Plinest polynucleotides:

• Improves skin elasticity and firmness
• Boosts hydration from within
• Reduces fine lines and signs of ageing
• Repairs damage and inflammation (ideal for acne scarring or rosacea-prone skin) 

Plinest is often referred to as a “bio-revitaliser” because it doesn’t just mask issues—it revitalises the skin at a cellular level, encouraging it to function like younger, healthier skin.

Exosomes are tiny extracellular vesicles naturally released by cells. Purasomes harness this power using stem-cell-derived exosomes, packed with growth factors, peptides, and cytokines that supercharge your skin’s natural repair mechanisms.

Why Purasomes are trending:

• Enhances skin cell communication for faster healing
• Brightens and evens skin tone
• Reduces inflammation and sensitivity
• Great for post-treatment recovery or general skin rejuvenation

Why These Two Are the Ultimate Pairing

Plinest polynucleotides and Purasomes exosomes are the dream team of regenerative skincare. Used together, they provide a multi-layered approach to rejuvenation:

• Plinest restores the structure and integrity of the skin
• Purasomes accelerate healing, brighten, and reduce inflammation 

It’s no wonder these two treatments are favoured by celebrities, patients and medical experts. They represent the next generation of skin treatments—natural, science-backed, and results-driven. Book a consultation today at our award-winning clinic!

If you are considering this treatment, learn more about polynucleotides in Birmingham at our city centre clinic.

We asked the public at The Mailbox — and then we turned to medical expert, Rebecca from DermaFocus, to explain what regenerative really means in the world of aesthetics.

Not sure yourself? Book a consultation to discover a cutting-edge approach to skin health

WATCH HERE

April is Rosacea Awareness Month, and we are teaming up with DermaFocus with a showcase event to raise awareness of this common, yet often misunderstood skin condition. 

Rosacea affects millions of people worldwide, causing persistent redness, sensitivity, and flare-ups that can impact confidence and overall skin health. At Dermoperfection, we are committed to providing the most advanced skincare solutions to help manage concerns like Rosacea. That’s why we are hosting a special week-long event in collaboration with DermaFocus, the creators of the award-winning Plinest polynucleotides and innovative exosome treatments.

What to Expect 

From the 9th to the 11th of April, we are inviting you to join us on Level 2, The Mailbox, located infront of Harvey Nichols and opposite Medicine Bakery, for a unique skincare experience. 

Featuring live demonstrations of cutting-edge treatments, giving you exclusive access to see first-hand how Plinest Polynucleotides and Exosomes can aid regeneration. Our expert practitioners will be on hand to offer in-depth skincare advice, guiding you through the best treatment options for Rosacea-prone and sensitive skin.

We will be welcoming guest speakers, to share their insights into the latest advancements in skincare and aesthetic medicine.  Expect exclusive giveaways, live demos, expert skincare advice, and much more. 

Why Plinest Polynucleotides & Exosomes?

We are pleased to showcase two revolutionary skincare advancements: Plinest polynucleotides and Exosomes, both leading in-clinic treatments for their regeneration and restorative properties.

Plinest, recently awarded Injectable Product of the Year at the 2025 Aesthetic Awards, is formulated with polynucleotides, naturally occurring molecules that deeply hydrate, repair, and strengthen the skin. 

These powerful ingredients help reduce inflammation, making Plinest an excellent treatment for those with sensitive and rosacea-prone skin. Additionally, polynucleotides work to stimulate collagen production, improving skin texture, elasticity, and overall health.

Exosomes, the latest breakthrough in regenerative skincare. These microscopic extracellular vesicles enhance cell-to-cell communication, delivering powerful growth factors, antioxidants, and anti-inflammatory benefits to the skin. Exosomes work alongside polynucleotides to accelerate healing, boost collagen synthesis, and restore skin balance, making them an ideal solution for individuals struggling with redness, irritation, and compromised skin barriers.

By combining Plinest Polynucleotides with Exosomes, we offer a next-generation approach to treating Rosacea and enhancing overall skin health.

The Importance of Rosacea Awareness Month

Rosacea Awareness Month is all about educating and empowering individuals who experience this chronic skin condition. Many people struggle to find effective solutions, but with advancements like Plinest polynucleotides and exosome therapy, there are now clinically proven treatments that can make a real difference.

This event is a fantastic opportunity to learn more about how to manage rosacea and discover the latest innovations in skin health and rejuvenation. We encourage everyone to take part, whether you personally experience rosacea or know someone who does. By attending, you will gain valuable skincare knowledge, expert advice, and access to exclusive treatment offers.

Join Us and Discover the Future of Aesthetics

This is an event you won’t want to miss! Join us between 9th–11th April at Dermoperfection, The Mailbox, and discover the benefits of Plinest Polynucleotides and Exosomes.